Genomic Investigations into Acute Inflammatory Lung Injury

Genomic insights into acute inflammatory lung injury.

Acute lung injury (ALI) is a devastating syndrome (usually associated with sepsis) that represents a major healthcare burden in the United States. We have focused our studies on unraveling the genetic underpinnings of this syndrome utilizing a candidate gene approach to identify novel genes for ALI susceptibility. Two novel genes identified by this approach include pre-B cell colony-enhancing f...

Regulation of Acute Lung Inflammatory Injury

Acute lung injury: how the lung inflammatory response works.

Acute lung injury in rodents (mice, rats) can be induced by intrapulmonary deposition of immunoglobulin (Ig)G immune complexes, which trigger an intense inflammatory response characterised by the influx of polymorphonuclear neutrophils (PMN), interstitial and alveolar oedema, and intra-alveolar haemorrhage [3]. This model of acute inflammation has been extensively evaluated in order to understa...

Functional genomic insights into acute lung injury: role of ventilators and mechanical stress.

Acute lung injury (ALI) is a complex and devastating illness, often occurring in the setting of sepsis and trauma. Despite recent advances in the understanding and treatment of ALI, pathogenic mechanisms and genetic modifiers in ALI remain incompletely understood. Furthermore, there has been increasing interest in the identification of genetic variations that contribute to ALI susceptibility an...

Bioinformatics insights into acute lung injury/acute respiratory distress syndrome

Bioinformatics is the application of omics science, information technology, mathematics and statistics in the field of biomarker detection. Clinical bioinformatics can be applied for identification and validation of new biomarkers to improve current methods of monitoring disease activity and identify new therapeutic targets. Acute lung injurt (ALI)/Acute respiratory distress syndrome (ARDS) aff...